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  • Title: Platelet prothrombin converting activity in hereditary disorders of platelet function.
    Author: Bevers EM, Comfurius P, Nieuwenhuis HK, Levy-Toledano S, Enouf J, Belluci S, Caen JP, Zwaal RF.
    Journal: Br J Haematol; 1986 Jun; 63(2):335-45. PubMed ID: 3718874.
    Abstract:
    Prothrombinase activities of platelets have been measured in diluted platelet-rich plasma using a chromogenic substrate assay and purified coagulation factors. No abnormalities in prothrombinase activities were found for platelets from patients with storage pool disease (dense-body deficiency), grey platelet syndrome, and Glanzmann's thrombasthenia. It is concluded that neither release of dense bodies and alpha-granules nor aggregation of platelets are essential prerequisites for exposure of a procoagulant surface. Platelets from patients with Bernard-Soulier syndrome, however, have approximately 10-fold higher prothrombinase activities in the non-stimulated form than normal non-stimulated platelets. The increased procoagulant activity cannot be completely ascribed to an increase in platelet size. It is suggested that the increased prothrombinase activity reflects an increased exposure of phosphatidylserine at the outer surface of non-stimulated Bernard-Soulier platelets, earlier described by Perret et al (1983).
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