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  • Title: Dystonia-Parkinson syndrome: differential effects of levodopa and dopamine agonists.
    Author: Klawans HL, Paleologos N.
    Journal: Clin Neuropharmacol; 1986; 9(3):298-302. PubMed ID: 3719575.
    Abstract:
    Eleven patients who presented with predystonic syndrome later developed pure dystonic syndromes and later developed parkinsonism. This suggests that dystonic syndromes can be the precursor to a mixed syndrome including both dystonia and parkinsonism. While the parkinsonian features in such patients respond to either levodopa or direct-acting agonists, levodopa often exacerbates the underlying dystonia. Direct acting agonists appear to be less liable to do this.
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