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  • Title: S-adenosyl-L-methionine modulates phosphatidylethanolamine methyltransferase response to isoproterenol in brain.
    Author: Zawad JS, Sulser F.
    Journal: Eur J Pharmacol; 1986 May 13; 124(1-2):157-60. PubMed ID: 3720835.
    Abstract:
    The effect of l-isoproterenol on S-adenosyl-L-methionine (Adomet)-mediated phospholipid methylation in rat brain cortex was examined. Under conditions which favor the activity of methyltransferase I (i.e. low Adomet), formation of phosphatidyl-N-methylethanolamine was inhibited by l-isoproterenol. On the other hand, methyltransferase II activity (i.e. high Adomet) was stimulated by l-isoproterenol. The results suggest that Adomet may play a regulatory role in the response of phospholipid methyltransferases to catecholamines in brain.
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