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  • Title: [Characteristics of induced aminopyrine N-demethylase].
    Author: Gerasimov KE, Mitrofanov DV, Tsyrlov IB.
    Journal: Farmakol Toksikol; 1986; 49(3):86-9. PubMed ID: 3720941.
    Abstract:
    The study of the inducing effect of phenobarbital on the activity of N-demethylase of aminopyrine in the rat liver microsomes revealed the correlation of the rate of enzymic reaction with the changes in the maximum binding of aminopyrine by cytochrome P-450 rather than with the content of hemoprotein itself. The comparison of the activity of N-demethylation of aminopyrine in control and phenobarbital-induced rats showed the quantitative correspondence of the yield of products of the reaction--formaldehyde in the liver microsomes and 4-aminoantipyrine in the urine samples. Self-induction of N-demethylating activity at repeated aminopyrine administration to rats and the dose dependence of this phenomenon were found.
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