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  • Title: Effects of buflomedil hydrochloride in occlusive arterial disease of the lower limbs stage IV.
    Author: Briguglio F, Briguglio E, Di Marco V, Swat M, Materia G, Intilisano A.
    Journal: J Int Med Res; 1986; 14(3):115-23. PubMed ID: 3721052.
    Abstract:
    Ten patients affected by occlusive arterial disease and presenting with skin lesions of the limbs were treated with buflomedil first i.v. and then orally, at a dosage of 600 mg/day. After a treatment period of 30 to 60 days, eight patients showed lesion regression with complete recovery; the remaining two patients dropped out of the study. The mechanism of action of buflomedil in healing skin lesions is also discussed.
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