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  • Title: Phenobarbital in prophylaxis of neonatal jaundice. A control trial of two regimens.
    Author: Salle B, Pasquer P, Desebbe C, Rouzioux JM, Barouty B.
    Journal: Helv Paediatr Acta; 1977 Sep; 32(3):221-6. PubMed ID: 372140.
    Abstract:
    The prevention of neonatal hyperbilirubinemia by phenobarbital is widely used in many countries. However, dose and period of administration vary according to authors, as the dose-effect relation is not known and since little research in pharmacokinetics of phenobarbital has been done so far. In the present study we compared the effect on serum bilirubin of a single injection of 10 mg/kg body weight and of a prolonged administration of 10 mg/kg/day during 3 days in premature and full-term newborn infants. The single injection had the same effect as the prolonged administration, provided it was given within 12 h after birth.
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