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  • Title: Guanosine 5'-diphosphate-3'-diphosphate inhibition of adenylosuccinate synthetase.
    Author: Stayton MM, Fromm HJ.
    Journal: J Biol Chem; 1979 Apr 25; 254(8):2579-81. PubMed ID: 372184.
    Abstract:
    The mechanism of ppGpp inhibition of adenylosuccinate synthetase (EC 6.3.4.4) was examined. Initial rate kinetic studies demonstrate the ppGpp inhibition is competitive with respect to GTP and noncompetitive with respect to L-aspartate and IMP. This is in contrast to an earlier report (Gallant, J., Irr, J., and Cashel, M. (1971) J. Biol. Chem. 246, 5812-5816), which suggested that ppGpp did not bind at the GTP site. Possible reasons for the discrepancy are discussed. The potency of the ppGpp inhibition is confirmed.
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