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  • Title: Effect of bromocriptine treatment on the fibrous tissue content of prolactin-secreting and nonfunctioning macroadenomas of the pituitary gland.
    Author: Esiri MM, Bevan JS, Burke CW, Adams CB.
    Journal: J Clin Endocrinol Metab; 1986 Aug; 63(2):383-8. PubMed ID: 3722328.
    Abstract:
    We performed a quantitative study using a point-counting technique at the light microscope level of the fibrous tissue content of PRL-secreting and nonfunctioning pituitary macroadenomas from patients treated or untreated with bromocriptine (BC) before surgery. There was a significant increase in the fibrous tissue content of PRL-secreting, but not nonfunctioning, tumors after BC treatment. The extent of the increase in fibrous tissue in prolactinomas correlated with the duration of treatment with BO.
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