These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Dual recognition elements for selective determination of progesterone based on molecularly imprinted electrochemical aptasensor.
    Author: Huang Y, Ye D, Yang J, Zhu W, Li L, Ding Y.
    Journal: Anal Chim Acta; 2023 Jul 11; 1264():341288. PubMed ID: 37230721.
    Abstract:
    A novel molecularly imprinted electrochemical aptasensor (MIEAS) was constructed for selective progesterone (P4) detection based on SnO2-graphene (SnO2-Gr) nanomaterial and gold nanoparticles (AuNPs). SnO2-Gr with a large specific area and excellent conductivity improved the adsorption capacity of P4. Aptamer, as biocompatible monomer, was captured by AuNPs on modified electrode through Au-S bond. An electropolymerized molecularly imprinted polymer (MIP) film consisted of p-aminothiophenol as chemical functional monomer and P4 as template molecule. Due to the synergetic effect of MIP and aptamer towards P4, this MIEAS exhibited better selectivity than the sensor with MIP or aptamer as single recognition element. The prepared sensor had a low detection limit of 1.73 × 10-15 M in a wide linear range from 10-14 M to 10-5 M. Satisfactory recovery obtained in tap water and milk samples proved that this sensor had great potential in environmental and food analysis.
    [Abstract] [Full Text] [Related] [New Search]