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  • Title: Effect of anticonvulsant drugs in vivo on rat pineal N-acetyltransferase (EC 2.3.1.5) and hydroxyindole-O-methyltransferase (EC 2.1.1.4).
    Author: Morton DJ.
    Journal: J Pineal Res; 1986; 3(2):181-6. PubMed ID: 3723330.
    Abstract:
    The effect of anticonvulsant drugs on daytime and nighttime N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT) levels was investigated. Some of the drugs caused a significant reduction in daytime NAT and HIOMT levels, possibly owing to beta-receptor blockade although other mechanisms cannot be excluded. Sulthiame caused an increase in daytime NAT levels, and this may represent a compensatory mechanism by the pineal gland to allow normal melatonin production. None of the drugs affected nocturnal HIOMT levels, and only phenobarbitone affected NAT levels, apparently causing a shift in the nocturnal peak later in the dark phase.
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