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  • Title: [Specific immunoglobulin and acyclovir in the prevention and treatment of varicella zoster infections in children with neoplastic diseases].
    Author: Lakomek M, Tillmann W, Schrewe H, Prindull G.
    Journal: Klin Padiatr; 1986; 198(3):281-4. PubMed ID: 3723992.
    Abstract:
    Immunocompromised children with acute leukemias and solid tumors are at high risk of fatal varicella infection. Reviewing a total of 242 patients at risk we have found that zoster immune plasma from reconvalescent patients (ZIP) and commercially available specific varicella/zoster immune globulin (VZIG) both prevent fatal disease. In addition, Acyclovir was effective against VZV-infections in this group of patients. We summarize our present policy of prophylaxis and treatment of immunocompromised children with neoplastic disease who have been exposed to VZV.
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