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  • Title: 2-Oxo-imidazole dipeptides inhibit peroxynitrite-dependent tyrosine nitration.
    Author: Matsukura K, Komae S, Kasamatsu S, Ihara H.
    Journal: Biochem Biophys Res Commun; 2023 Aug 06; 668():77-81. PubMed ID: 37244038.
    Abstract:
    Carnosine and anserine were reported to inhibit tyrosine nitration. However, there are no reports on the nitration inhibitory activities of balenine, 2-oxo-carnosine, 2-oxo-anserine, and 2-oxo-balenine. We demonstrated for the first time that these compounds exhibit inhibitory activities against peroxynitrite-dependent tyrosine nitration. 2-Oxo-imidazole dipeptides (2-oxo-IDPs) showed higher inhibitory activity than their precursor IDPs, thereby suggesting that 2-oxo-IDPs may be effective against nitrative stress-related diseases.
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