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Title: Intraorbital lymphatic-venous malformation in an adult patient: is sirolimus the key? Author: Ruiz Velasco Santacruz A, Nieva Pascual I, Cifuentes Canorea P, Díaz Ramírez S, Pascual González M. Journal: Orbit; 2024 Aug; 43(4):535-538. PubMed ID: 37262366. Abstract: Intraorbital lymphatic-venous malformations are rare lesions that represent a therapeutic challenge given their location and high rate of recurrence, with only a few cases in adult patients having been published in the literature. We present the case of a 30-year-old male with a right intraorbital lymphatic-venous malformation treated with sirolimus at a dose of 4 mg/day with complete clinical and radiologic remission. Mild cold-like symptoms ensued during the first week of treatment and elevation of liver function enzymes and D-dimer occurred in the context of acute SARS-CoV-2 pneumonia. No major adverse effects were documented. After 18 months of treatment, the patient remains asymptomatic and ophthalmologic examinations including optical coherence tomography and visual field test are within normal values.[Abstract] [Full Text] [Related] [New Search]