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  • Title: [Status of the uterine mucosa during long-term intrauterine contraception].
    Author: Petrov IuA.
    Journal: Sov Med; 1986; (5):103-4. PubMed ID: 3726613.
    Abstract:
    Structural, functional, and morphological parameters of the endometrium were examined during and after long-term intrauterine contraception. The study included 638 women, aged 19-48, who had been using a Lippes' Loop for .4-12 years; the control group consisted of 96 women who were planning to use intrauterine contraception. Endometrial samples were treated with a 10% formalin solution, histologically processed, and embedded in paraffin. The sections were stained with a hematoxylineosin reagent using the van Gieson method. In 474 women using IUDs, no pathological changes of the endometrium were observed. IUDs did not cause atypical hyperplasia or cancer of the endometrium. Thus, the study shows that in most women using IUDs, the condition of the uterine mucosa was normal. Long-term (over 60 months), continuous IUD use increased the occurrence of some pathological changes of the endometrium, including chronic nonspecific endometritis, focal fibrosis of stroma, and atrophic changes of the mucosa. It is concluded that the clinical symptoms observed during long-term IUD use lack specificity and do not reflect deep morphological changes of the endometrium.
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