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  • Title: The vitamin K-antagonism of salicylate and warfarin.
    Author: Roncaglioni MC, Ulrich MM, Muller AD, Soute BA, de Boer-van den Berg MA, Vermeer C.
    Journal: Thromb Res; 1986 Jun 15; 42(6):727-36. PubMed ID: 3726797.
    Abstract:
    When administered in high dosages, salicylate acts as a vitamin K-antagonist: it induces a decrease of the plasma concentration of the Gla-containing coagulation factors and an accumulation of microsomal substrates for vitamin K-dependent carboxylase in the liver and in the lung. In vitro the drugs inhibit the DTT-dependent reductases which mediate the reduction of vitamin K epoxide and vitamin K quinone. NADH-dependent reductase and vitamin K-dependent carboxylase are not inhibited.
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