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  • Title: Multi-biomarkers hazard assessment of microplastics with different polymers by acute embryo test and chronic larvae test with zebrafish (Danio rerio).
    Author: Chen Y, Duan M, Xu X, Wu C.
    Journal: Aquat Toxicol; 2023 Jul; 260():106595. PubMed ID: 37269673.
    Abstract:
    Microplastics as emerging contaminants show various composition features in the environment. However, influence of polymer types on the toxicity of microplastics is still unclear, thus affecting evaluation of their toxicity and ecological risks. In this work, toxic effects of microplastics (fragment, 52-74 μm) with different polymer types including polyethylene (PE), polyethylene terephthalate (PET), polypropylene (PP) and polystyrene (PS) to zebrafish (Danio rerio) were studied using acute embryo test and chronic larvae test. Silicon dioxide (SiO2) was used as a control representing natural particles. Results showed microplastics with different polymers had no influence on embryonic development at environmental relevant concentration (102 particles/L), but could lead to accelerated heartbeat rate and increased embryonic death when exposed to SiO2, PE and PS at higher concentrations (104 and 106 particles/L). Chronic exposure for zebrafish larvae indicated different polymers of microplastics did not affect zebrafish larvae' feeding and growth, nor induce oxidative stress. But larvae' locomotion level and AChE (acetylcholinesterase) activities could be inhibited by SiO2 and microplastics at 104 particles/L. Our study demonstrated negligible toxicity of microplastics at environmental relevant concentration, while different polymers of microplastics have similar toxic effects as SiO2 at high concentrations. We suggest that microplastic particles may have the same biological toxicity as natural particles.
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