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  • Title: Adrenocortical adenoma with Cushing's syndrome. Scanning electron microscopic observations.
    Author: Matsuo K, Tsuchiyama H.
    Journal: Acta Pathol Jpn; 1986 Apr; 36(4):543-9. PubMed ID: 3728011.
    Abstract:
    Adrenocortical adenomas with Cushing's syndrome (Cushing's adenoma) consisted of two different features, which intermingled in various proportions and were related with each other. The first feature showed long-columnar or trabecular arrangement and a vacuolar appearance which correspond to lipid droplets of clear-type cells. In the second feature, the sinusoid was well developed and meandering, and the perisinusoidal space was prominent and contained collagen fibrils, bleb-like structures, and granules. The collagen fibrils were entangled with the parenchymal cells. The sinusoid was lined by a sinusoidal wall with fenestrations or pores. Bleb-like structures and granules traversed them. Two different features were speculated to be consistent with areas of clear-type cells and compact-type cells, respectively, observed light and transmission electron microscopies.
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