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  • Title: Efficient preparation of hyperoside and quercitrin from Zanthoxylum bungeanum Maxim leaves using an integrated surfactant-based aqueous two-phase system, back-extraction and adsorption separation.
    Author: Han N, Chen X, Wang H, Wang N, Nian M, Wang D.
    Journal: Nat Prod Res; 2024 Sep; 38(18):3188-3200. PubMed ID: 37287217.
    Abstract:
    Zanthoxylum bungeanum leaves (ZBL) are of great medicinal value for being rich in hyperoside and quercitrin. In this study, a novel, efficient and economical continuous process was established. First, aqueous two-phase system (ATPS) composed of Triton X-100/(NH4)2SO4 was employed to enrich hyperoside and quercitrin from ZBL extracts and the recoveries reached 98.53% and 99.12%. Then back-extraction with dichloromethane-water system was adopted to separate hyperoside and quercitrin from Triton X-100 micelles which were recycled and the recoveries reached 86.58% and 85.19%. Finally, S-8 macroporous resin was used for removing the salt introduced in ATPS and the final recoveries reached 82.38% and 81.81%, much higher than the total flavonoids recovery as 69.08%. Furthermore, scale-up experiment certified that the continuous process was feasible for industrial production. Efficiently and economically, this method achieved a great breakthrough in purity and provided a novel reference for further purification and phase-forming component recycle.
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