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  • Title: Comparative pharmacokinetics of azlocillin and piperacillin in normal adults.
    Author: Colaizzi PA, Polk RE, Poynor WJ, Raffalovich AC, Cefali EA, Beightol LA.
    Journal: Antimicrob Agents Chemother; 1986 May; 29(5):938-40. PubMed ID: 3729353.
    Abstract:
    The single-dose pharmacokinetics of azlocillin and piperacillin were compared by using a randomized, crossover design. The concentrations of azlocillin in serum were consistently higher than those of piperacillin throughout an 8-h study. The area under the time-concentration curve of azlocillin was significantly greater than that of piperacillin, and the total body clearance of azlocillin was significantly lower than that of piperacillin.
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