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  • Title: Chronic pernio. A historical perspective of cold-induced vascular disease.
    Author: Jacob JR, Weisman MH, Rosenblatt SI, Bookstein JJ.
    Journal: Arch Intern Med; 1986 Aug; 146(8):1589-92. PubMed ID: 3729641.
    Abstract:
    Chronic pernio, or cold-induced vascular disease, is an uncommon syndrome with a clinical resemblance to vasculitis or peripheral cholesterol embolization. We studied a case of chronic pernio in which the angiogram revealed extensive vascular changes indistinguishable from vasculitis; pathologic studies of previously reported cases have revealed a primary vasculopathy. The pathophysiology of chronic pernio may be cold-induced vessel damage leading to a secondary dermopathy. Our patient's condition improved once the correct diagnosis was established and appropriate therapy was instituted.
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