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  • Title: [Effect of vitamin E on the oxidative metabolism of macrophages].
    Author: Sharmanov AT, Aĭdarkhanov BB, Kurmangaliev SM.
    Journal: Biull Eksp Biol Med; 1986 Jun; 101(6):723-5. PubMed ID: 3730561.
    Abstract:
    The oxidative metabolism of macrophages in vitamin E deficiency was studied on Aug-Lac strain rats. Vitamin E deficiency was shown to enhance luminol-dependent chemiluminescence of macrophages stimulated by opsonized zymosan. There was also an increase in microviscosity of macrophage membrane lipid phase, that was estimated with a fluorescent probe. The incubation of macrophages with dl-alpha-tocopherol led to the inhibition of macrophage chemiluminescence. Superoxide dismutase, glutathione peroxidase and glutathione reductase activity was not affected by vitamin E deficiency.
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