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  • Title: [Relation between the toxic killing of mouse small intestine enterocytes and the interval between the administration of the S-specific agent hydroxyurea].
    Author: Churikova LI, Krinskaia AV, Dibrov BF, Zhabotinskiĭ AM, Neĭfakh IuA.
    Journal: Biull Eksp Biol Med; 1986 Jun; 101(6):746-9. PubMed ID: 3730566.
    Abstract:
    The dependence of small intestinal lesions on the interval between repeated regular injections of hydroxyurea was studied. The doses of 1 g/kg and 0.2 g/kg were used. To activate the enterocyte proliferation the mice were pre-irradiated at 2 Gy. 3-4 hours after the last hydroxyurea injection the two distinct minimum points of epithelial lesions were observed at interinjection intervals of 9 and 16.5 hours. The result was dose-independent.
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