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  • Title: M-Type Phospholipase A2 Receptor Autoantibody Measured by ELISA has Diagnostic Value in Patients with Idiopathic Membranous Nephropathy.
    Author: Li J, Mulatibieke A, Liu S, Adelibieke Y, Dai C, Chahan S, Chen H.
    Journal: Clin Lab; 2023 Jun 01; 69(6):. PubMed ID: 37307127.
    Abstract:
    BACKGROUND: This study investigated the diagnosis value of phospholipase A2 receptor autoantibodies (PLA2R-AB) for idiopathic membranous nephropathy (IMN). METHODS: Patients with IMN, lupus nephritis, hepatitis B virus-associated nephropathy and IgA nephropathy and healthy participants were included. Receiver operating characteristics (ROC) curve was plotted for PLA2R-AB to diagnose IMN. RESULT: The level of serum PLA2R-AB was significantly higher in patients with IMN than with other MN, and was positively correlated to urine albumin-creatinine ratio and proteinuria in patients with IMN. The area under the ROC curve displaying the performance of PLA2R-AB to diagnose IMN was 0.907 with a sensitivity and specificity of 94.3% and 82.1%, respectively. CONCLUSIONS: PLA2R-AB is a reliable biomarker to diagnose Chinese patients with IMN.
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