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  • Title: Subcellular distribution of cytochrome P-450 in the brain.
    Author: Walther B, Ghersi-Egea JF, Minn A, Siest G.
    Journal: Brain Res; 1986 Jun 11; 375(2):338-44. PubMed ID: 3730827.
    Abstract:
    The subcellular distribution of the monooxygenase complexes in the brain was studied by using subcellular fractionation and characterization of these fractions by marker enzymes. Cytochrome P-450 was found to be mainly localized in both synaptic and non-synaptic mitochondria; only a small quantity of enzyme was also found in the microsomal fraction. Peeling off the outer membrane of mitochondria showed that the protein was retained in the inner membrane fraction. A comparative study among some other species confirmed the mitochondrial prevalence of cerebral cytochrome P-450. A partial purification of the rat brain mitochondrial P-450 was obtained.
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