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  • Title: A comparative, double-blind study on tolfenamic acid in the treatment of rheumatoid arthritis.
    Author: Rejholec V, Vapaatalo H, Tokola O, Gothoni G.
    Journal: Scand J Rheumatol Suppl; 1979; (24):13-6. PubMed ID: 373084.
    Abstract:
    Sixty patients with diagnosed rheumatoid arthritis were treated at random with tolfenamic acid, a new nonsteroid anti-inflammatory analgesic, in a daily dose of 600 mg, or with phenylbutazone 300 mg or acetylsalicylic acid 1,500 mg daily. Both the patients and the physician found that tolfenamic acid had a clearly better effect than phenylbutazone or the low-dose acetylsalicylic acid used as a control. Tolfenamic acid and acetylsalicylic acid were well tolerated. Serious side-effects (leukopenia and thrombocytopenia in one case, hematemesis and melena in another) only occurred in those patients who received phenylbutazone.
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