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  • Title: [Therapy of duodenal ulcer with cimetidine, pirenzipine and placebo: report on a double-blind randomized study].
    Author: Giger M, Gonvers JJ, Weber KB, Sonnenberg A, Birchler R, Mattle W, Hofstetter JR, Blum AL.
    Journal: Schweiz Med Wochenschr; 1979 Apr 21; 109(16):617-8. PubMed ID: 373105.
    Abstract:
    A double-blind randomized controlled study with pirenzepine (75 mg/day), cimetidine (1 g/day) and placebo was performed in 50 consecutive out-patients with duodenal ulcer. The patients also received an antacid containing aluminium hydroxide. Pirenzepine, cimetidine and placebo had similar effects on the 4-week healing rate. Dryness of the mouth was more frequent with pirenzepine than with the other two types of treatment. The incidence of other side effects did not differ in the three groups. A tendency towards more rapid disappearance of subjective symptoms in the patients treated with pirenzepine was not statistically significant. In conclusion, pirenzepine and cimetidine were not superior to placebo in the treatment of duodenal ulcer.
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