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  • Title: Effects of erythromycin, josamycin and spiramycin on rat polymorphonuclear leukocyte chemotaxis.
    Author: Eyraud A, Descotes J, Lombard JY, Laschi-Loquerie A, Tachon P, Veysseyre C, Evreux JC.
    Journal: Chemotherapy; 1986; 32(4):379-82. PubMed ID: 3731922.
    Abstract:
    The effects of three macrolide antibiotics were studied on rat polymorphonuclear leukocyte chemotaxis. Rats were given 25 mg/kg twice a day of either erythromycin, josamycin or spiramycin by gastric intubation for 5 days. In all cases, chemotaxis was found to be impaired by 10-20% only. As macrolides are known to reach high intracellular concentrations within polymorphonuclear leukocytes, our results suggest that these antibiotics are unlikely to exert a deleterious influence on the chemotactic response of treated patients.
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