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  • Title: Evaluation by 31P NMR of the effects of acebutolol on the ischaemic isolated rat heart.
    Author: Lavanchy N, Martin J, Giacomelli M, Rossi A.
    Journal: Eur J Pharmacol; 1986 Jun 24; 125(3):341-51. PubMed ID: 3732396.
    Abstract:
    We used 31P NMR spectroscopy to study the effect of acebutolol on the metabolic disturbances caused by ischaemia in the isolated rat heart. The intracellular acidosis and high-energy phosphate compound depletion induced by global low-flow ischaemia were significantly attenuated in the presence of acebutolol 2.7 X 10(-5) and 1.35 X 10(-4) M. The drug displayed no significant effect either at the 5.4 X 10(-6) M concentration or when administered as pretreatment to the animals (50 mg X kg-1, 120 and 60 min before isolating the heart). Since acebutolol had no effect on the contractility of the isolated rat heart at the 2.7 X 10(-5) M concentration the present results suggest that the mechanisms through which acebutolol exerts its effects on energy metabolism are not related to a reduction of cardiac work. The possible contribution of the membrane-stabilizing property of the drug is suggested by the fact that high concentrations are needed and that a short pretreatment had no effect.
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