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  • Title: Ketoconazole does not impair antipyrine clearance in humans.
    Author: Blyden GT, Abernethy DR, Greenblatt DJ.
    Journal: Int J Clin Pharmacol Ther Toxicol; 1986 May; 24(5):225-6. PubMed ID: 3733272.
    Abstract:
    The effect of ketoconazole on the kinetics of antipyrine was investigated. The antipyrine Vd showed an overall difference among the 4 trials, but the magnitude of the differences was small. Antipyrine half-life was slightly but not significantly shortened and the antipyrine clearance was essentially identical in the whole study. The data are commented and interpreted.
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