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  • Title: In vitro conversion of proinsulin to insulin by cathepsin B and role of C-peptide.
    Author: Puri RB, Anjaneyulu K, Kidwai JR, Mohan Rao VK.
    Journal: Acta Diabetol Lat; 1978; 15(5-6):243-50. PubMed ID: 373354.
    Abstract:
    Cathepsin B, purified from isolated islets of Langerhans, when incubated with proinsulin under in vitro conditions could convert proinsulin to insulin and C-peptide, releasing free arginine and lysine. When C-peptide, prepared from rat pancreas, was added to the incubation system consisting of proinsulin and cathepsin B, it completely inhibited the conversion of proinsulin to insulin.
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