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  • Title: Does maintenance therapy with alpha interferon stabilize cancer growth? A pilot study.
    Author: Laszlo J, Goldstein D, Vugrin D, Hood L, Tso CY.
    Journal: J Biol Response Mod; 1986 Aug; 5(4):294-9. PubMed ID: 3734845.
    Abstract:
    A pilot study was undertaken to test whether alpha interferon (alpha-IFN) maintenance could continue to stabilize cancer measurements after induction therapy. Twenty-one patients who achieved stable disease at the end of their induction treatment were randomized to receive weekly maintenance with human lymphoblastoid interferon (HLBI) (3 MU/m2, i.m.) or to be followed and not given interferon. There were 12 patients in the maintenance groups and 9 in the control observation group. There was no time difference in disease progression between the two arms. This article considers the relevance of the stable disease category in trials of interferon.
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