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  • Title: [The influence of dopamine of kidney function during continuous positive-pressure ventilation (PEEP) (author's transl)].
    Author: Augusin HJ, Bischoff K, Engels T.
    Journal: Anaesthesist; 1979 Apr; 28(4):159-62. PubMed ID: 373493.
    Abstract:
    In a group of 20 patients the influence of continuous positive-pressure Ventilation (PEEP) on cardiac output, kidney function and renal and intrarenal hemodynamics was investigated. During ventilation with PEEP 10 ccm H2O a reduction of cardiac output, glomerular filtrationrate, sodium excretion and urinary output was observed. Renal blood flow, especially the cortical fraction, also decreased. Dopamine infusion, in a dose of 4 ng.kg-1.min-1, during continuous PEEP-ventilation, induced an increase of cardiac output, glomerular filtrationrate, renal sodium excretion and diuresis. The decreased renal cortical perfusion particularly was improved by Dopamine application.
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