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  • Title: Chemical composition and acetylcholinesterase inhibitory activity of essential oil from the leaves of Mitrephora poilanei Weeras. & R.M.K. Saunders.
    Author: Doan TQ, Dinh D, Nam Tran T, Quynh Dinh Nguyen P, Bao Hoai Nguyen C, Trong Le N, Vo HQ, Ho DV, Tuan AL, Nguyen HT, Ogunwande IA.
    Journal: Nat Prod Res; 2024 Jun; 38(11):1882-1886. PubMed ID: 37357615.
    Abstract:
    The present study provides the first information on the chemical composition and acetylcholinesterase inhibitory activity of the essential oil (EO) from the leaves of Mitrephora poilanei Weeras. & R.M.K.Saunders from Vietnam. Gas chromatography and gas chromatography-mass spectrometry analysis revealed that the main components of the M. poilanei EO were β-caryophyllene (13.2%), α-humulene (10.5%), germacrene D (8.1%), β-elemene (5.2%) and bicyclogermacrene (5.1%). The anti-acetylcholinesterase assay showed that the EO displayed moderate activity with IC50 value of 31.16 ± 3.06 μg/mL. These findings proposed that the plant can be exploited for its anti-acetylcholinestrate potential.
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