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  • Title: Multicomponent Reaction: Pd/Cu-Catalyzed Borocarbonylation of Aryldiazonium Salts with Aliphatic Terminal Alkynes to gem-Bis(boryl) Ketones.
    Author: Zhu F, Yin P.
    Journal: Chemistry; 2023 Sep 26; 29(54):e202301826. PubMed ID: 37369918.
    Abstract:
    We report the development of Pd/Cu-catalyzed selective 2,1-borocarbonylation reactions of aliphatic terminal alkynes with aryldiazonium salts and B2 Pin2 to prepare gem-bis(boryl) ketones in one-pot. A series of corresponding products are obtained with good to excellent yields under a carbon monoxide atmosphere (10 bar). In addition, wide functional-group tolerance can be observed. Preliminary mechanistic studies reveal that ethyl acetate serves as a proton source in the reaction.
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