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  • Title: Mecamylamine blockade of nicotine responses: evidence for two brain nicotinic receptors.
    Author: Collins AC, Evans CB, Miner LL, Marks MJ.
    Journal: Pharmacol Biochem Behav; 1986 Jun; 24(6):1767-73. PubMed ID: 3737641.
    Abstract:
    Mice of two inbred strains, DBA and C3H, were pretreated with mecamylamine before challenge with nicotine. Mecamylamine blocked nicotine-induced seizures, enhanced startle, and alterations in respiratory rate, Y-maze activity, heart rate and body temperature. Mecamylamine blocked nicotine-induced seizures and enhanced startle with IC50 values of less than 0.1 mg/kg. The other nicotine effects were blocked by mecamylamine with IC50 values between 0.8 and 2.3 mg/kg. Strain differences in sensitivity to mecamylamine blockade were also detected. These results suggest that nicotine elicits its effects at two receptors, which may be those labeled with [125I]-alpha-bungarotoxin and with [3H]-nicotine.
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