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  • Title: Serological aspects of rat tumour xenograft growth in athymic nude mice.
    Author: Pimm MV, Baldwin RW.
    Journal: Br J Cancer; 1979 Feb; 39(2):116-21. PubMed ID: 373782.
    Abstract:
    The serum of athymic nude mice bearing rat tumour xenografts has been examined for tumour-specific antigen. With a sarcoma and a hepatoma, tumour-specific antigen expression continued in xenograft growths, and sera of tumour-bearing mice contained free antigen, assayed by its ability to neutralise reactivity of tumour-immune rat sera against tumour target cells in an indirect membrane-immunofluorescence test. In contrast, no anti-rat antibody was detectable in sera of mice bearing the xenografts, or rejecting cells injected in admixture with BCG.
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