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  • Title: Single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine.
    Author: Doberstyn EB, Phintuyothin P, Noeypatimanondh S, Teerakiartkamjorn C.
    Journal: Bull World Health Organ; 1979; 57(2):275-9. PubMed ID: 373903.
    Abstract:
    A single oral dose (1.5 g) of mefloquine hydrochloride cured all of 37 patients with falciparum malaria, and a single dose of pyrimethamine (75 mg) plus sulfadoxine (1.5 g) cured 34 of 38 patients. The rates at which parasitaemia and fever abated were similar for the two regimens but mefloquine was associated with a higher incidence of gastrointestinal side effects.
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