These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The effect of sodium benzoate on ammonia toxicity in rats.
    Author: Maswoswe SM, Cyr DM, Griffith AD, Tremblay GC.
    Journal: Biochem Biophys Res Commun; 1986 Jul 16; 138(1):369-73. PubMed ID: 3741416.
    Abstract:
    At 9.5 mmoles/kg body weight, sodium benzoate sharply increased mortality in rats subsequently challenged with ammonia. Fasted animals were less sensitive to potentiation of ammonia toxicity by benzoate than were fed animals. At 2.5 mmoles/kg body weight, benzoate was observed to protect fasted animals against ammonia toxicity. Measurements of ammonia disappearance, urea formation, and hippurate synthesis in suspensions of isolated hepatocytes indicate that benzoate potentiates ammonia toxicity by inhibiting the urea cycle.
    [Abstract] [Full Text] [Related] [New Search]