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  • Title: A high melting cis-[Pt(NH3)2[d(GpG)]]adduct of a decanucleotide duplex.
    Author: van Hemelryck B, Guittet E, Chottard G, Girault JP, Herman F, Huynh-Dinh T, Lallemand JY, Igolen J, Chottard JC.
    Journal: Biochem Biophys Res Commun; 1986 Jul 31; 138(2):758-63. PubMed ID: 3741432.
    Abstract:
    The [cis-Pt(NH3)2(d(GCCGGATCGC)-N7(4), N7(5))]-d(GCGATCCGGC) duplex has been prepared with Tm = 49 degrees C (vs 58 degrees C for the unplatinated form). NMR of the ten observable imino protons supports a kinked structure with intact base pairing of the duplex on the 3'-side of the d(GpG).cis-Pt chelate (relative to the platinated strand) The modification of the B-DNA type CD spectrum, due to the platinum chelate, is comparable to that observed for the platination (at a 0.05 Pt:base ratio) of the Micrococcus Lysodeikticus DNA (72% GC).
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