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  • Title: No significant net uptake of branched chain amino acids by the liver of fed-mid pregnant rats.
    Author: Pastor-Anglada M, Remesar X.
    Journal: Biochem Int; 1986 Jun; 12(6):957-62. PubMed ID: 3741451.
    Abstract:
    The hepatic balance for valine, leucine and isoleucine has been measured in anaesthetized virgin controls and 9 and 12-day pregnant rats. The liver of non gravid animals show fractional extraction rates of over 11.6% for valine, 17.6% for leucine and 16.8% for isoleucine. Fed mid-pregnant rats do not show either a significant net uptake nor a release of these amino acids. It is proposed that higher intestinal amino acid requirements for protein synthesis during mid pregnancy than before impregnation may be, in part, the cause of a decreased hepatic uptake and, thus, a different role for the liver in the amino acid inter-organ relationships during this period is suggested.
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