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  • Title: [Systemic antibiotic prophylaxis with metronidazole in elective colonic and rectal surgery. Results of a clinical controlled study and a critical literature review].
    Author: Raetzel G, Harnoss BM, Görtz G, Häring R, Rodloff A.
    Journal: Arzneimittelforschung; 1986 Jun; 36(6):976-80. PubMed ID: 3741534.
    Abstract:
    The pathogen spectrum of wound infections in colon surgery is composed almost exclusively of facultatively aerobic and obligatorily anaerobic intestinal flora. A study was performed in which a one-shot prophylaxis was carried out by applying metronidazole, 500 mg i.v., or latamoxef (lamoxactam) 2 g i.v., on induction of anesthesia. The metronidazole group evidenced a 26.3% incidence of infections due exclusively to aerobic pathogens. In the latamoxef (lamoxactam) group, it was possible to achieve a reduction of the postoperative rate of wound infections to 11.1%. The study was prematurely terminated because of the high rate of wound infections in the metronidazole group and the exclusive selecting of aerobic pathogens.
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