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  • Title: Preliminary experience with controlled-release aminophylline in asthmatic children: salivary levels and peak flow following a single dose.
    Author: Evans N, Evans PW, Boobis SW.
    Journal: J Int Med Res; 1979; 7 Suppl 1():93-7. PubMed ID: 374166.
    Abstract:
    Preliminary experience of a controlled-release aminophylline tablet in twenty-five asthmatic children has been gained by measuring salivary theophylline levels and peak flow after a single dose (11 mg/kg). The results were compared with an oral theophylline preparation. Mean salivary levels remained elevated at eight hours following ingestion of controlled-release aminophylline, at which time 58% of the children continued to show an improvement in peak flow. Individual children showed a wide variation in salivary levels and respiratory response. It is recommended that theophylline levels should be monitored in the saliva to ensure maximum benefit from the drug.
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