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  • Title: [Effect ot tuftsin on cerebral monoamine oxidase and acetylcholinesterase activity].
    Author: Dovedova EL.
    Journal: Biull Eksp Biol Med; 1986 Aug; 102(8):155-7. PubMed ID: 3742025.
    Abstract:
    The administration of a tetrapeptide tuftsin at a dose of 300 mkg/kg body weight for 30, 75 min or 3 days leads to the changes in specific activity of monoamine oxidase, forms A and B, and acetylcholinesterase in synaptosomal and cellular mitochondrial subfractions from the rabbit sensorimotor cortex and nucleus caudatus. The reciprocity of neuro-transmitter systems and specific peptide effects on the brain structures have been demonstrated. The results suggest that tuftsin has an activating effect on dopamine metabolism.
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