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  • Title: Low dose aminoglutethimide (125 mg twice daily) with hydrocortisone for the treatment of advanced postmenopausal breast cancer.
    Author: Harris AL, Cantwell BM, Sainsbury JR, Needham G, Evans RG, Dawes PJ, Wilson R, Farndon J.
    Journal: Breast Cancer Res Treat; 1986; 7 Suppl():S41-4. PubMed ID: 3742063.
    Abstract:
    Aminoglutethimide 125 mg twice daily and hydrocortisone 20 mg twice daily was used to treat 76 postmenopausal women with advanced breast cancer. There were 4 CR, 17 PR (objective response rate 28%). Highest response was in soft tissue. CNS toxicity was less than with conventional dose AG (drowsiness 7% v. 31%), although the incidence of rash was equivalent. Previous responders to tamoxifen had a higher response (33%) than previous non-responders (9%). The lower toxicity and maintained efficacy suggest that this should be the standard dosage regimen.
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