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  • Title: Propressophysin is present in neurones at multiple sites in Wistar and homozygous Brattleboro rat brain.
    Author: van Leeuwen FW, Caffé R, van der Sluis PJ, Sluiter AA, van der Woude TP, Seidah NG, Chrétien M.
    Journal: Brain Res; 1986 Jul 30; 379(1):171-5. PubMed ID: 3742211.
    Abstract:
    Vasopressin (VP) is synthesized as propressophysin, containing also neurophysin (NP) and C-terminal glycopeptide (CPP), within the hypothalamo-neurohypophyseal system (HNS). Recently, VP and NP-immunoreactive cells were demonstrated in other rat brain nuclei. Here we report CPP immunoreactivity in perikarya in these nuclei. Within the homozygous Brattleboro rat, known to be deficient in neuronal VP production, no CPP immunoreactivity was seen in these nuclei. However, intense VP and CPP immunoreactivity was present in solitary cells (52.2 +/- 3.3 per rat) and fibres within the HNS.
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