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  • Title: A facile ratiometric near-infrared fluorescent probe using conjugated 1,8-naphthalimide and dicyanoisophorone with a vinylene linker for detection and bioimaging of hypochlorite.
    Author: Zhang Z, Ma L, Huang Y, Zhou Y, Zhang H, Yan J, Liu C.
    Journal: Anal Methods; 2023 Jul 20; 15(28):3420-3425. PubMed ID: 37427555.
    Abstract:
    A new ratiometric near-infrared fluorescent probe 3 for detecting ClO- using conjugated 1,8-naphthalimide and dicyanoisophorone with a vinylene linker was reported. Probe 3 exhibited a ratiometric signal (I705/I535), large Stokes shift (205 nm), high selectivity and sensitivity, low detection limit (0.738 μM), rapid response (within 3 s) and good biocompatibility. The sensing mechanism involved the oxidation of the olefin double bond by ClO- to release the initial N-butyl-4-hydroxyl-3-formyl-1,8-naphthalimide 1, followed by inhibition of an ICT process from the electron-donor 4-hydroxyl-1,8-naphthalimide to dicyanoisophorone. At the same time, the probe 3-loaded test strips were applied in sensing of ClO- with moderate "naked-eye" color changes. Additionally, probe 3 has been successfully used for ratiometric bioimaging of ClO- in HeLa cells with low cytotoxicity.
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