These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Fine specificity and idiotype expression of anti-phosphorylcholine IgE and IgG antibodies.
    Author: Weber EA, Heusser CH, Blaser K.
    Journal: Eur J Immunol; 1986 Aug; 16(8):919-23. PubMed ID: 3743632.
    Abstract:
    The immune response to the phosphorylcholine (PC) hapten elicited in BALB/c mice by PC-keyhole limpet hemocyanin (KLH) is composed of 2 groups of antibodies with specificity to PC and phenyl-PC, respectively. They were designated as group I and group II anti-PC antibodies. In this report we demonstrate that anti-PC IgE antibodies elicited by PC-KLH or PC-ovalbumin belong to the group II and do not express the T15 idiotype. Anti-PC IgG1, IgG2a and IgG2b antibodies express group I characteristics in the primary response and bear the T15 idiotype. Later, after 5 weeks and 3 injections of PC-KLH or PC-ovalbumin, a change in these isotypes to group II antibodies is observed. In contrast, anti-PC IgE is a group II antibody throughout progression of the immune response. The regulation of group I and group II antibody expression in serum is independent of the genetic background of the animals.
    [Abstract] [Full Text] [Related] [New Search]