These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A comprehensive atlas of perineuronal net distribution and colocalization with parvalbumin in the adult mouse brain.
    Author: Lupori L, Totaro V, Cornuti S, Ciampi L, Carrara F, Grilli E, Viglione A, Tozzi F, Putignano E, Mazziotti R, Amato G, Gennaro C, Tognini P, Pizzorusso T.
    Journal: Cell Rep; 2023 Jul 25; 42(7):112788. PubMed ID: 37436896.
    Abstract:
    Perineuronal nets (PNNs) surround specific neurons in the brain and are involved in various forms of plasticity and clinical conditions. However, our understanding of the PNN role in these phenomena is limited by the lack of highly quantitative maps of PNN distribution and association with specific cell types. Here, we present a comprehensive atlas of Wisteria floribunda agglutinin (WFA)-positive PNNs and colocalization with parvalbumin (PV) cells for over 600 regions of the adult mouse brain. Data analysis shows that PV expression is a good predictor of PNN aggregation. In the cortex, PNNs are dramatically enriched in layer 4 of all primary sensory areas in correlation with thalamocortical input density, and their distribution mirrors intracortical connectivity patterns. Gene expression analysis identifies many PNN-correlated genes. Strikingly, PNN-anticorrelated transcripts are enriched in synaptic plasticity genes, generalizing PNNs' role as circuit stability factors.
    [Abstract] [Full Text] [Related] [New Search]