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  • Title: Inhibition of the mitochondrial tricarboxylate carrier by arginine-specific reagents.
    Author: Stipani I, Zara V, Zaki L, Prezioso G, Palmieri F.
    Journal: FEBS Lett; 1986 Sep 15; 205(2):282-6. PubMed ID: 3743778.
    Abstract:
    The effect of arginine-specific reagents on the activity of the partially purified and reconstituted tricarboxylate carrier of the inner mitochondrial membrane has been studied. It has been found that 1,2-cyclohexanedione, 2,3-butanedione, phenylglyoxal and phenylglyoxal derivatives inhibit the reconstituted citrate/citrate exchange activity. The inhibitory potency of the phenylglyoxal derivatives increases with increasing hydrophilic character of the molecule. Citrate protects the tricarboxylate carrier against inactivation caused by the arginine-specific reagents. Other tricarboxylates, which are not substrates of the carrier, have no protective effect. The results indicate that at least one essential arginine residue is located at the substrate-binding site of the tricarboxylate carrier and that the vicinity of the essential arginine(s) has a hydrophilic character.
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