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  • Title: Patterns of serum LH and FSH in response to 4-hour infusions of luteinizing hormone releasing hormone in normal women during menstrual cycle, on oral contraceptives, and in postmenopausal state.
    Author: de Kretser DM, Burger HG, Dumpys R.
    Journal: J Clin Endocrinol Metab; 1978 Feb; 46(2):227-35. PubMed ID: 374423.
    Abstract:
    Patterns of serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) in response to 4-hour infusions (1 mcg/min) of LH-releasing hormone in 16 normal women during the menstrual cycle, in 4 women on oral contraceptives (OCs), and in 3 postmenopausal women were investigated. A biphasic response of LH was observed in the follicular and luteal phases, with the response much larger in the latter (p .001). The largest LH response was observed during the periovulatory phase (p .001). Women on combined OCs studied between Cycle Days 11-14 showed a biphasic response intermediate in magnitude (p .05) between follicular and luteal phases with some blunting of the initial phase of secretion. FSH response was not clearly biphasic but was greatest in the periovulatory phase (p .001), intermediate in the luteal phase (p .01), and least in the follicular phase. In postmenopausal women, total output of LH was similar to the luteal phase and the output of FSH was equivalent to that at midcycle. These data support the concept that the biphasic response to LH to the prolonged infusion is present in women and that its magnitude and characteristics may be modulated by estradiol and progesterone levels.
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